This paper analyzes the methodological and publication trends in the literature on cross-border mergers and acquisitions over three five-year periods,1996–2001, 2001–06, and 2006–11. Based on a selection of 23 journals and a sample of 170 articles, we use advanced cross-tabulations to study the publication and methodological trends that have emerged in North America, Europe, and other regions. Our main findings are as follows. A+-rated journals tend to accept the use of regression as a key technique. Top-tier journals accept papers primarily in finance and accounting and international business. Researchers’ interest in international business has increased at a rising rate, and increased at a falling rate in finance and accounting. The publication of conceptual quantitative articles has increased significantly by 45 percent over the 15-year period. About 98 percent of the total sample uses modeling as a methodology and is accepted by A+- and A-rated journals. Cross-sectional studies are more popular than longitudinal studies. The financial institutions industry has been studied the most in all parts of the world and at an increasing rate over the period under review. Researchers’ interest in manufacturing industries has, however, declined over the 15 years in all regions.